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OXFORD, Miss. — A plane crash in Tuscaloosa, Alabama is reverberating throughout the Mid-South.

All six people killed were returning from a dental conference in Florida and were headed to Oxford when Jason Farese reported having engine problems and sent out a distress call around 11: 10 a.m. Sunday.

Rescue crews were ready but the plane never reached the airport according to Tuscaloosanews.com.

The plane crashed in a wooded area.

Killed were Dr. Austin Poole and his wife, Angie Poole, who had a dental clinic in Clarksdale.

Dr. Michael Perry and his wife Kim Perry operated a dental clinic in Oxford as well as the Oxford-Lafayette Sportsplex.

Dr. Jason Farese and his wife Dr. Lea Farese. They were dentists at Farese Family Dental in Oxford.

Together, they leave behind 11 children.

“That just doubled the tragedy in my mind,” Clarksdale Mayor Bill Luckett said. “Austin and Angie have both been clients of mine as a lawyer and have been friends of mine.”

Luckett also said related to the couple.

The plane, a Piper PA-31, is registered to an address that matches that of Farese Family Dental.

The National Transportation Safety Board and the FAA are investigating the crash.